The diagnosis of Lyme borreliosis is based on clinical manifestations and history of exposure to ticks in an endemic area. Clinical manifestation of Lyme borreliosis may be similar to that of other diseases and serological detection of Borrelia antibodies represents a fundamental aid to diagnosis. Tests with high diagnostic accuracy are particularly important for differential diagnosis since additional factors complicate serological findings:

• early stage of infection may not show a measurable immune response
• IgM antibodies may persist for months
• cross-reaction with other spirochaete proteins, or other infectious diseases or autoimmune disorders may cause false positive antibody response

DiaSorin offers Borrelia on the LIAISON® systems.