Brain Damage Markers

DiaSorin offers the S100 and NSE on LIAISON® systems.


LIAISON® S100 is a quantitative automated chemiluminescent immunoassays (CLIA) for the in vitro determination of protein S-100B in human serum and CSF (Cerebrospinal fluid). LIAISON® S100 is intended for use as an aid in the management of patients suffering from malignant melanoma. The test has to be performed on the LIAISON® Analyzer family.


A lack of reliable biochemical markers has hampered efforts to understand the mechanisms behind the complications resulting from these disorders. Neurological examinations and neuropsychological testing, together with various imaging techniques, are common methods for assessing cerebral injury. However, these methods are expensive and time-consuming.
Beyond its application as tumour marker for melanoma, protein S-100B is highly specific for glial cells and has very high sensitivity for brain damage. Clinical studies show immediate release of this marker after brain injury into the blood. S100 is also a useful marker for monitoring brain damage and detecting secondary neurological injuries. In recent years much interest has been focused on the S-100B protein, now recognized as a useful marker for brain damage. The value of S-100 in head injury, cardiac arrest and stroke has been demonstrated in a very large number of publications.
Furthermore Enolase (NSE), which is an enzyme involved in glucose metabolism (catalyses the conversion of 2-phospho-Dglycerate to phospho-enol-pyruvate) is found in malignant tumours, has also been used as a marker in different kind of cerebral diseases such us traumatic brain injury, stroke and circulatory arrest. Enolase is mainly used for monitoring the severity of the injury and as an early predictor of outcome.