DiaSorin offers the adrenal line measuring ACTH and Cortisol on the RIA format and LIAISON® systems.
The LIAISON® ACTH assay uses chemiluminescent immunoassay (CLIA) technology for the in vitro quantitative determination of Adrenocorticotropic hormone in human EDTA-plasma specimens (stored frozen). The determination of ACTH in conjunction with other laboratory tests and clinical findings can help in investigating adrenal dysfunction in humans. The test has to be performed on the LIAISON® Analyzer family.
In vitro assay for the quantitative determination of cortisol in human serum, plasma (and urine). The test has to be performed on the LIAISON® Analyzer.
The LIAISON® DHEA-S assay uses chemiluminescent immunoassay (CLIA) technology for the in vitro quantitative determination of dehydroepiandrosterone sulphate in human serum or plasma specimens. The test has to be performed on the LIAISON® Analyzer.
Two important markers related to Adrenal Function are ACTH and Cortisol.
Adrenocorticotropic hormone (ACTH) is a hormone produced in the pituitary gland to stimulate secretion of the hormone cortisol by the adrenal glands. Cortisol is important for regulating glucose, protein and lipid metabolism; suppressing the immune response; and maintaining blood pressure. Normally, ACTH increases when cortisol is low and falls when cortisol is high. ACTH levels in the blood are tested to help diagnose Cushing's syndrome, Addison's disease and tumours of the pituitary and adrenal glands. Measuring both ACTH and cortisol can help sort out some of the causes of these conditions. Because the level of ACTH normally changes in the opposite direction to the level of cortisol, is important to identify an imbalance in this relationship and the direction in which the imbalance occurs. For example, if cortisol level is high and ACTH level is also increased, that would indicate that there is a pituitary disease that causes production of too much ACTH. Furthermore blood and urine tests for cortisol are used to help diagnose Cushing’s syndrome and Addison’s disease, two serious disorders affecting the production of cortisol by the adrenal gland. Cushing's syndrome is caused by too much cortisol, while Addison's disease is caused by damage to the adrenal gland and is associated with too little cortisol. If cortisol concentrations are abnormal, additional testing may be required to confirm the diagnosis and decide on treatment. These further tests may involve a test to suppress cortisol production with dexamethasone or a test to stimulate the adrenal gland to produce cortisol, using a synthetic form of ACTH.