Clinical Areas

Bone Metabolism

Bones allow us to move, give our shape and support our body. They are dynamic tissues that rebuild constantly throughout our life. During childhood and teens, the body adds new bone faster than it removes old bone. After age 20, some people can lose bone faster than making bone. To have strong bones and prevent bone loss when older, we need to get enough calcium, vitamin D and exercise.
There are many kinds of bone problems:

  • Low bone density and osteoporosis make your bones weak and more likely to break
  • Osteogenesis imperfecta makes bones brittle
  • Paget's disease of bone makes them weak
  • Bones can also develop cancer and infections

DiaSorin is the recognized leader in immunoassay testing of bone health. 25-OH-VitD testing is in the world still the most widely adopted test to monitor VitD levels in blood. Insufficient levels of VitD are a key cause of weak bones.
The most recent and innovative assay generated by DiaSorin scientists in bone metabolism monitoring is the VitD 1,25 assay. This is the first and only fully automated assay to detect and quantify VitD 1,25 levels in blood not requiring any complex and manual sample manipulation. Testing of VitD 1,25 is the active metabolite of VitD that regulates calcium absorption in our body. This unique and unprecedented test is based upon the new technology invented by DiaSorin scientists termed “Receptor-mediated Immunoassay”.

 

Infectious Diseases

DiaSorin has one of the widest automated immunoassays portfolio in the world for detection and quantitation of infective agents in biological fluids. As of today, we have more immunoassays available on the market to make diagnosis of viral and bacterial infections and blood bank testing.
Viral infections rank among the biggest causes of death worldwide. With HIV or hepatitis viruses, early detection and viral load monitoring are crucial to managing disease treatment, as well as in identifying strains of the virus that have developed drug resistance. DiaSorin provides automated tests to directly detect and quantify viral load of hepatitis B and C, HIV, along with tests for cytomegalovirus (CMV). DiaSorin is the undisputed world leader in immunodetection of the so termed ToRCH infections, which include Toxoplasma, Rubella, Cytomevalovirus and Herpes, a group of conditions that need to be monitored very closely during pregnancy for the risk of transmission to the fetus.
Recently the new HIV combo assay has been launched. This assay on the automated LIAISON® XL platform detects simultaneously the presence in blood of HIV antigens and of antibodies, allowing simple and rapid early diagnosis in case of recent infection.
Each year, more than 80 million units of donated blood are stored and distributed worldwide. DiaSorin provides blood banks with highly sensitive and automated immunoassays to detect HIV, hepatitis B & C and HTLV helping to ensure that blood supplies are safe and free from serious infectious diseases before they are used. Recently, DiaSorin scientists developed a new assay for detection of Chagas disease in blood banks.
Being world leader in immunoassays for infectious diseases, DiaSorin is committed to continuously improve the Infection Disease products. We constantly improve our assays to meet customer expectations and excellence. New improved versions of our Infectious Disease products are being generated, including, among the others, new assays for detection of EBV.

 

Hormones

Hormones are a heterogeneous class of molecules produced by some organs in human body that, once released into the bloodstream, influence other organs activities. For example, estrogen and testosterone are sexual hormones produced by reproductive organs and that affect many organs in our body, determining different body mass in males and females, hair distribution, voice timbre, and so on.
Measuring hormones levels, for example thyroid hormones or sex hormones, is essential to detect a great number of diseases.
DiaSorin developed the first fully automated assay for the quantitative determination of Aldosterone, an essential hormone in the regulation of blood pressure. DiaSorin has been the first company to create an easy, reliable and automated assay to measure Aldosterone in blood and urine. This assay will enable physicians to diagnose secondary arterial hypertension caused by an excessive amount of Aldosterone.

 

GI Stool testing

Most of diseases are diagnosed through markers measured in blood and urine, but as some others have not such reliable markers, they can only be identified by analyzing markers present in stool specimens.
This happens in gastrointestinal infections (for example the severe C. Difficile generally in nosocomial patients) and in inflammatory and autoimmune bowel diseases (such as ulcerative colitis and Chron’s disease).
The detection and characterization of markers in stool samples can be a complex and manual process, and thus, expensive. Moreover, as it is a manual process it does not provide quick answers and manipulation errors may occur in testing.
DiaSorin researchers have been the first to automate immunometric stool testing, creating automated assays for the detection of toxins A and B of Chlostridium Difficile and Helicobacter Pylori bacteria. These automated, fast and reliable in vitro assays will enable physicians to start adequate antibiotic therapies in diseases treatments.
Moreover, DiaSorin designed and created a special test tube in which patients collect stool specimens to analyze. This test tube is directly used in the in vitro diagnosis, without any further transfer (that means moving stool specimen to other test tubes) which increases the risk of contamination.
DiaSorin, through its research and development activities, is creating new assays intended for automated and immunometric stool testing to treat various gastrointestinal tract infectious diseases, inflammatory and autoimmune bowl diseases. Thanks to DiaSorin’s activities, stool testing will be faster and more reliable.

 

 

 

 

 

 

 

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