Stool Diagnostics

Most gastrointestinal infections are self-limited and resolve within a few days. However, in newborns/infants, immunocompromized patients or elderly populations, gastrointestinal infections can be potentially serious. Diagnosis of gastrointestinal infections is largely performed through laboratory tests used for culture or antigen detection from stool specimens.
Clostridium difficile is a gram positive, spore-forming bacillus that produces two exotoxins: toxin A and toxin B. These toxins are responsible for the diarrhea and inflammation seen in infected patients. Toxin A is an enterotoxin that can cause extensive mucosal damage and is an activator of mast cells and neutrophils, which trigger inflammatory mediators. Toxin B is a cytotoxin that is known to cause morphological changes in tissue culture cells.
Helicobacter pylori is a spiral shaped bacterium, living in the mucus of the human digestive tract and is present in half of the world population. Strongly associated with peptic ulcer disease and chronic active gastritis, H. pylori is a major risk factor for gastric adenocarcinoma.
Diagnosis of infection can be achieved by non-invasive methods, such as detection of H. pylori antigens in stool sample. The H. pylori stool antigen assay provides a simple alternative to the urea breath test and is appropriate for diagnosis and follow-up of infection.

LIAISON® Campylobacter

The LIAISON® Campylobacter assay uses chemiluminescent immunoassay (CLIA) technology for the qualitative determination of Campylobacter antigens in human stool specimens. The test may be used as an aid in the diagnosis of acute bacterial gastroenteritis. The assay must be performed on the LIAISON® Analyzer family.

LIAISON® Calprotectin

The DiaSorin LIAISON®  Calprotectin  Assay is an in vitro diagnostic chemiluminescent immunoassay (CLIA) intended for the quantitative measurement, in human stool, of fecal calprotectin, a neutrophilic protein that is a marker of mucosal inflammation. The LIAISON® Calprotectin Assay can be used as an aid in the diagnosis of inflammatory bowel diseases (IBD), specifically Crohn’s disease and ulcerative colitis, and as an aid in differentiation of IBD from irritable bowel syndrome (IBS). Test results are to be used in conjunction with information obtained from the patients’ clinical evaluation and other diagnostic procedures.
The test has to be performed on the LIAISON® Analyzer Family.

LIAISON® C. difficile GDH

The DiaSorin LIAISON® C. difficile GDH Assay is a chemiluminescent immunoassay (CLIA) intended for use as a screening assay to detect Clostridium difficile antigen, glutamate dehydrogenase, in human feces from persons suspected of having C. difficile disease

 

LIAISON® C. difficile Toxins A and B

The DiaSorin LIAISON® C. difficile Toxins A&B Assay is a chemiluminescent immunoassay (CLIA) intended for the qualitative determination of Clostridium difficile toxins A and B in human feces on the LIAISON® Analyzer. Assay results should be used in conjunction with other clinical and laboratory data to assist the clinician in making individual patient management decisions.

LIAISON® H. pylori SA

The DiaSorin LIAISON® H. pylori SA is a chemiluminescent immunoassay (CLIA) intended for the qualitative determination of H. pylori stool antigen in human feces on the LIAISON® Analyzer. The test is an aid in the diagnosis of H. pylori infection and to monitor response during and post-therapy in patients. Assay results should be used in conjunction with other clinical and laboratory data to assist the clinician in making individual patient management decisions.

LIAISON® Rotavirus

The DiaSorin LIAISON® Rotavirus assay is an in vitro diagnostic chemiluminescent immunoassay (CLIA) intended for the qualitative determination of rotavirus antigen in human stool specimens. This test is used primarily as an aid for the diagnosis of acute viral gastroenteritis. Test results are to be used in conjunction with information obtained from the patients’ clinical evaluation and other diagnostic procedures. The assay must be performed on the LIAISON® Analyzer.

LIAISON® Adenovirus

The DiaSorin LIAISON® Adenovirus assay is an in vitro diagnostic chemiluminescent immunoassay (CLIA) intended for the qualitative determination of adenovirus antigen in human stool specimens. This test is used primarily as an aid for the diagnosis of acute viral gastroenteritis. Test results are to be used in conjunction with information obtained from the patients’ clinical evaluation and other diagnostic procedures. The assay must be performed on the LIAISON® Analyzer Family*.

LIAISON® EHEC

The DiaSorin LIAISON® EHEC Toxins assay is an in vitro diagnostic chemiluminescent immunoassay (CLIA) intended for the qualitative detection of Shiga toxins 1 and 2 in stool specimens, broth cultures, and from individual colonies or colony sweeps of agar plates. The LIAISON® EHEC Toxins assay is intended for use as an aid in the diagnosis of Enterohemorrhagic E. coli (EHEC) infections. Test results are to be used in conjunction with information obtained from the patients’ clinical evaluation and other diagnostic procedures. The assay must be performed on the LIAISON® Analyzer Family.